As soon as you exit Thailand your current visa exemption is canceled..
When you re-enter you will get another 60 day exemption..
However your entry to Thailand is always at the discretion of the Immigration officer you are dealing with on the day..
If for whatever reason they believe you are not a genuine tourist and abusing the visa exemption entry system to live in Thailand you can be refused entry..
I am not sure about the US requirements as I am Australian but I assume it's similar and there are difficulties and strict requirements particularly for younger Asian women.
They generally must demonstrate some ties back to Thailand to indicate they plan to return..
Family and a steady job are usually the minimum and also enough money to support themselves during their stay.
You may also be required to offer a letter of invitation for her and make a commitment to cover accommodation and other expenses it needed.
Those are just a few points I have heard though friends trying to get a tourist visa into Australia for women from just about anywhere in SE Asia and I expect the US has similar requirements.
Has she been making the visa application herself or through an agent?
In some cases the agents can be helpful as they are familiar with meeting all the requirements to satisfy immigration.
Unfortunately you have the cost of the Agent fees as well