Can I extend my Non O visa while married to a Thai national and frequently traveling?

Okay, sounds like you haven't been renewing anything :O

BUT sounds like you've been getting a brand NEW year-long, multi-entry Non-O visa from a thai consulate in another country.

I honestly don't think you're in country long enough to manage to get thru the yearly extension process. Once you apply you get a 30 day under consideration stamp AND during that 30 days then come to your house to do an in home visit then you go back on that date and get the extension inked in. you HAVE to be in country for the in home visit AND have to be back here on the date your 30 day under consideration stamp comes up when you go in for the extension to be inked in.

Another thing is meeting the proof of funds by using monthly income (If you are from the US, UK, Australia or Denmark) you would need to transfer into the country in a thai bank account in your name only a minimum of 40K baht a month for the previous 12 months before you apply for your yearly extension.

I would say the year-long, multi-entry Non-O visa is actually the perfect 'fit' for your work/travel restrictions right now. There's no down side in getting them for many many years.