How far in advance can you apply for a NON-O (Thai Spouse) Visa extension before it expires?

I believe that the OP has the answers needed for his question.

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I was told 45 days before is OK in the Buriram immigration office. Very quiet, every time I've visited.

Tough to pin down seeing as you didn't mention which of the 80+ immigration offices you get your yearly extension at 😕

You're safe at ALL offices applying when you have 30 days or less left on your current stamp. (y)

You don't lose any time going early because the next year extension is added to your expiration date..

SOME offices allow you to do it when you have 45 days or less left (Bangkok, Chiang Mai, etc) but you're always safe with 30 or less :)