Can I perform a visa run in Thailand on weekends?

Visa run no because the embassies are closed. Border bounce yes.

for others the e-visa for a 6 month multiple entry is considerably different than the older Thai Canadian embassy one (of which I had 6 pre-COVID...loads of documentation is requested other than what is outlined in the application which you pay up front , and can delay approval (out of the Canadian office for some reason) for months ..I had to enter visa exempt , for example.. since flight was booked and only later was my actual Visa application approved and received by e-mail.

My recent experience at Chiang Khong with exactly same type of M (multiple entry) 6 month visa (issued out of Canadian Thai Embassy) was on a Sunday..an excellent day to do it. Not busy and simple straight forward procedure.

Carry Thai baht (do not confuse actual stay and wait in Laos for an actual visa application where often American currency is encouraged)...have available the e-mail print out of your Visa since , though innocuous looking as compared to the traditional plate type insert you will receive on Lao side..it shall be your official visa document ). You will receive 60 days and shall get same for unlimited crossings until visa expiry date clearly marked on your approval doc....also found there is VISA # which you use for your TM6 card (still used at land borders) for re-entry.

If you live far from Lao land crossings ...and wish to get a 30 day extension (example..last stamp before leaving for good) you can visit a local Immigration Office and pay 1900 baht if approved.)

Both processes are quite different though and will be recorded as such.

No you can't. Embassies and consulates are closed at the weekend

Boarder bouncing, yes no problem.

Yes