Shouldn't have any issue at all doing "tourist stuff" in S/E Asia using Thailand as a base of travel. It's done all the time.
US passport gets in for 60 days free stamp (visa exempt) each time you enter. Your planned travel sounds normal and wouldn't raise flags stamping into thailand multiple times at all.
Remember you need to file a TDAC (Thailand Digital Arrival Card) each time you enter the country using the online web-portal
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Safe travels (y)