Are there any issues I should be aware of when traveling from Thailand to Pakistan and back with a re-entry permit?

Traveling from Thailand to Pakistan and back is generally feasible, especially since you have a re-entry permit and are fully vaccinated. The main requirement is obtaining a ThailandPass to re-enter Thailand, which may involve some additional steps. Currently, there shouldn't be any travel bans preventing your return, apart from standard health provisions like potential PCR test requirements.