Can you take a big bus from Kanchanaburi to Chiang Mai?

Yes! You can!

Or take the train.

Indeed, two direct buses a day

I use Rome2Rio

@Ed *******

yes bus Terminal

6.00 in the morning and 18.00 evening and takes 10 t 11houers

Walk over to a couple of the many tourist information counters you will meet, when you walk around.

No matter what you want to do, you can get advise there, they are the most knowledgeable people about what is going on, at the destination.

Then you will get a real live person, to help you finding the best tours / transport or what your need, and if they don’t provide excellent service, easy to pick another.

They have the local knowledge about almost everything a tourist need.

Tours / transport can be booked just 1-2 days ahead, in that way, it’s possibel to take the weather in account, which you can’t do by booking weeks or month ahead online.

And as a extra bonus, you will support local people by dealing directly with them.

If anything goes wrong, you will know where to contact face to face.

Not sure if either have direct buses.

Yes night bus

yes, @ the bus terminal