Will leaving Thailand after 2 months on a Non-O visa affect my visa status?

No just get a rentry permit before you fly out easy

I guess you are looking at living long term in Thailand? If you arrive on a 90 day Non-O visa you get stamped in for 90 days and can extend that for a further 12 months at your local immigration office. But for you there are a couple of logistical issues to work round. You can apply for the 12 month extension when you have 30 days (45 in a few places) or less left on that 90 day stamp but in order to do so you must also have had a minimum of 800k baht in a Thai bank account for 2 months. If you leave in that initial 90 days you'll need a re-entry permit and also to be back in time to apply for the 12 month extension of stay else you will need to apply for another 90 day Non-O visa before you return to Thailand. If you leave Thailand after getting the 12 month extension of stay you will also need a re-entry permit to keep that 12 month stamp alive

you could buy a single re-entry permit for 1000 THB for the 90-days stay permit. It will keep the stay permit alive for one exit and re-entry. But you will not gain any more days - the re-entry permit only gets you stamped in for the remainder of your initially stamped 90-days stay permit

on a Non-Imm-O Retirement Visa you will get stamped in for a 90-days stay permit. If you leave Thailand after two months (before the 90-days stay permit expires) the stay permit will become void. You would need to apply again, or re-enter visa-exempt and will (should the visa-exemption get set back from 60 to 30 days) get stamped in for 30 days. For this entry you would (probably) need to show the three famous proofs: booked accomodation for a few nights, 20,000 THB in cash (can be in another currency) and an onward travel proof out of Thailand within the first 30 days